By Denise Thompson
Healthday Reporter

WEDNESDAY, March 10, 2021 ( Information) – with lots of older older people Insanity Risky combinations of medicines are prescribed that increase their threat additional than enough, Falls and further more psychological drop, finds a new research.

About 1 to 7 folks with dementia residing outside nursing houses are using 3 or a lot more medication that act on them Brain and anxious program, Scientists reported.

The most disturbing mixture integrated drugs, A distinguished professor Drs. Donovan Mast’s famous scientists Psychiatry At the Educational Medical Middle of the College of Michigan Healthcare, Michigan.

Approved for opioids ache, But they warn of a black box overdose and demise demanded by the US Meals and Drug Administration if they are taken along Enzodiazepines, Antipsychotics and anti-seizure medicines, Mast claimed.

“Approximately 50 percent of the top 20 mixtures contain an opioid furthermore other CNS[central nervous system-related medications],” he claimed.[centralnervoussystemdepressantmedications”hesaid[केंद्रीयतंत्रिकातंत्रअवसादग्रस्तदवाएंशामिलथीं”उन्होंनेकहा।[centralnervoussystemdepressantmedications”hesaid

For this study, Maust and his colleagues analyzed 2018 Medicare prescription data on more than 1.2 million people with dementia, focusing specifically on drugs that act on the central nervous system.


Researchers said that people over the age of 65 should not be given three or more CNS-active drugs at the same time, because the interaction of the drugs can be dangerous, the researchers said, background notes.

Nevertheless, about 14% of dementia patients were taking three or more CNS-active medications at the same time for at least a month, the results showed.

Of that group, about 58% were on at least three overlapping medications for more than half a year, and 7% for the entire year, Must said.

The most common combination included at least one antidepressant, an anti-epileptic, and an antipsychotic, Mast said.

Very often, these drugs are prescribed for purposes other than their function, the researchers said.

For example, the most commonly prescribed drug was gabapentin, an anti-seizure drug often prescribed off-label to treat pain, Mast said. It accounted for one-third of all days of prescription supplies to patients in 2018.

And at least 47% of those taking three or more drugs had at least one antipsychotic, often prescribed to dementia patients for agitation and insomnia.


More than 9 out of 10 patients taking three or more drugs were on an antidepressant, and approximately two-thirds were on an anti-seizure medication.

The problem is that there is a greater risk than benefit for patients when taken in combination with these drugs, Must said.

“For most of these drugs, the evidence that they help is very beautiful,” Maust said. “On the other hand, there is a lot of evidence that there are risks associated with them.”

For example, drugs that work on the brain and nervous system are at increased risk of malfunction.

“Too much of all these drugs are associated with an increase in falls and fall-related injuries, which can have a catastrophic outcome for older adults,” Musta continued.

There is also some evidence that antidepressants and antipsychotics may actually contribute to memory loss and dementia patients.

“Obviously, it is very worrying for dementia patients that you will give them medications that actually cause further deterioration in their cognition,” Must said.


Geriatrist psychiatrist Mast said that “one of my favorite things is to try to stop medicines, because people can end up on a lot of different medications.”

His team published the findings on 9 March Journal of the American Medical Association.

Dr. Howard Fillitt, as the executive director and chief science officer of the Alzheimer’s Drug Discovery Foundation, said doctors treating seniors should regularly review the drug. He was not part of the new research.

“Whenever I see a new patient, I always ask them to empty their medicine cabinet, put it in a bag, bring it to my office. We’re going to put it on our table and we’re Going through every phase. One single of them, “said Filit, a clinical professor of geriatric medicine with the Icahn School of Medicine at Mount Sinai in New York City.

“It can be very complicated,” Flete continued. “Sometimes people were put on drugs five or 10 years ago, they didn’t even know why they were. Sometimes people were put on the same medicine by two different doctors, and Doctors do not detect the patient as imitating drugs. “


Must said that a drug review can ensure that dementia patients receive medicines that are important to their well-being while reducing their risk of harm.

“It is important to note that there is certainly concern about the pain that occurs in older adults,” Must said. “For someone with dementia who deals with behavior, it’s possible that they’re experiencing pain they can’t articulate. It’s really important that their pain is treated. So my question would be That’s what led to that other drug. ” ‘again? “

more information

The US National Institute on Aging is more about Medication management for Alzheimer’s patients.

Source: Donovan Mast, MD, Associate Professor, Psychiatry, Michigan Medicine; Howard Fillitt, MD, Executive Director and Chief Science Officer, Alzheimer’s Drug Discovery Foundation, and Clinical Professor, Geriatric Medicine and Palliative Care, founder of Econ School of Medicine in Mount Sinai, New York City; Journal of the American Medical Association, 9 March, 2021